Most adrenal gland disorders affect only the adrenal cortex, one of the gland's two distinct zones. The adrenal cortex primarily produces the hormones cortisol and aldorestone. Hormone and adrenal testing, particularly, blood tests are capable of identifying the various disorders in the adrenal gland through the measurement of these different hormones. We will learn about the benefits of amino acids testing with regards to how the levels of these hormones are measured, and how they are used to assess adrenal malfunction.
Hormones and Adrenal Testing - Cortisol
Blood cortisol is one of the basic tests used to assess adrenal gland function. Cortisol levels rise and fall throughout the day, rendering a single blood sample ineffective when diagnosing any deficiencies or overproduction. To get a better sense of adrenal function, doctors require multiple samples throughout the day to measure cortisol levels before or after stimulation.
Hormones and Adrenal Testing - Adrenocorticotropin Hormone
Adrenocorticotropin hormone, or ACTH, is a hormone made by the pituitary gland that influence the production of cortisol. ACTH levels are indicative of the state of adrenal function and can be measured to reach diagnosis. If the adrenal glands are not working properly, the pituitary secretes more ACTH to stimulate the production of cortisol. People with poorly functioning adrenal glands typically have elevated levels of ACTH.
Adrenal Stimulation Test - Cosyntropin
If a 24 hour sampling is not possible, doctors suggest the stimulation of the adrenal glands with a synthetic form of ACTH called cosyntropin. Blood cortisol level is measured before injection of cosyntropin. After 45 minutes, the blood cortisol level is again measured to see if the adrenal glands produced more cortisol in response to the stimulation. Failure of the blood cortisol level to rise indicates adrenal gland malfunction.
Corticotropin-Releasing Hormone
Another adrenal stimulation test is done through the use of a corticotropin-releasing hormone, a chemical that stimulates the release of ACTH. The baseline levels of ACTH and cortisol are measured before the injection of the chemical. Cortisol and ACTH levels are measured every 15 minutes to check reaction. ACTH levels usually peak after 15 to 30 minutes, while cortisol levels at 30 to 40 minutes after the injection. Failure of cortisol levels to rise after an increase in ACTH indicates adrenal failure.
Blood tests measuring hormone levels are among the trusted laboratory tests to assess adrenal malfunction. If you are suffering from adrenal fatigue, adrenal stress or any symptoms related to adrenal disorder, talk to your doctor for a possible testing today.
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